Scientific Source #13 – Peer-Reviewed Article
“We have discovered that a single sperm protein, phospholipase C-zeta (PLCζ), can stimulate intracellular Ca(2+) signalling in the unfertilized oocyte (‘egg’) culminating in the initiation of embryonic development. Upon fertilization by a spermatozoon, the earliest observed signalling event in the dormant egg is a large, transient increase in free Ca(2+) concentration. The fertilized egg responds to the intracellular Ca(2+) rise by completing meiosis“13
13Nomikos, M., Swann, K., & Lai, F.A., Starting a new life: sperm PLC-zeta mobilizes the Ca2+ signal that induces egg activation and embryo development: an essential phospholipase C with implications for male infertility, Bioessays, 2012, 34(2):126-34, https://pubmed.ncbi.nlm.nih.gov/22086556.
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