Posts Tagged ‘Peer-Reviewed Article’

“Recognition between sperm and the egg surface marks the beginning of life in all sexually reproducing organisms”15 15Raj, I., Sadat, A.l., Hosseini, H., Dioguardi, E., Nishimura, K., Han, L., Villa, A., de Sanctis, D., & Jovine, L., Structural Basis of Egg Coat-Sperm Recognition at Fertilization, Cell, 2017, 169(7):1315-1326, https://pubmed.ncbi.nlm.nih.gov/28622512.

“Sperm are remarkably complex cells with a singularly important mission: to deliver paternal DNA and its associated factors to the oocyte to start a new life”34 34Wu, T.F. & Chu, D.S., Sperm chromatin: fertile grounds for proteomic discovery of clinical tools, Mol Cell Proteomics, 2008, 7(10):1876-86, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2559940.

“Pronuclear/zygotic stage is the very first stage of life”16 16Okada, Y. & Yamaguchi, K., Epigenetic modifications and reprogramming in paternal pronucleus: sperm, preimplantation embryo, and beyond, Cell Mol Life Sci, 2017, 74(11):1957-1967, https://pubmed.ncbi.nlm.nih.gov/28050628.

“One of the most fundamental developmental transitions occurs at fertilization when two haploid gametes join to initiate the development of a multicellular organism.”17 17Nader, N., Kulkarni, R.P., Dib, M., & Machaca, K., How to make a good egg!: The need for remodeling of oocyte Ca(2+) signaling to mediate the egg-to-embryo transition, Cell Calcium, 2013, 53(1):41-54,…

“[F]ertilization is the process by which male and female haploid gametes (sperm and egg) unite to produce a genetically distinct individual”18 18Signorelli, J., Diaz, E.S., & Morales, P., Kinases, phosphatases and proteases during sperm capacitation, Cell Tissue Res, 2012, 349(3):765, https://www.researchgate.net/publication/221715537_Kinases_phosphatases_and_proteases_during_sperm_capacitation.

“Ca2+ signaling plays a crucial role in virtually all cellular processes, from the origin of new life at fertilization to the end of life when cells die”19 19Santella, L., Ercolano, E., & Nusco, G.A., The cell cycle: a new entry in the field of Ca2+ signaling, Cell Mol Life Sci, 2005, 62(21):2405-13, https://pubmed.ncbi.nlm.nih.gov/16003492.

“Mammalian embryo development begins when the fertilizing sperm triggers a series of elevations in the oocyte’s intracellular free Ca(2+) concentration”20 20Machaty, Z., Signal transduction in mammalian oocytes during fertilization, Cell Tissue Res, 2016, 363(1):169-83, https://www.researchgate.net/publication/282732457_Signal_transduction_in_mammalian_oocytes_during_fertilization.

“Membrane fusion has an overarching influence on living organisms. The fusion of sperm and egg membranes initiates the life of a sexually reproducing organism.”21 21Marsden, H.R., Tomatsu, I., & Kros, A., Model systems for membrane fusion, Chem Soc Rev, 2011, 40(3):1572, https://pubmed.ncbi.nlm.nih.gov/21152599.

“It is intuitive that fertilization-the start of life-involves communication between a sperm cell and an egg”22 22Asano, A., Nelson-Harrington, J.L., & Travis, A.J., Membrane rafts regulate phospholipase B activation in murine sperm, Commun Integr Biol, 2013, 6(6):e27362, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984294/pdf/cib-6-e27362.pdf.

“Mammalian life, with all its complexity comes from a humble beginning of a single fertilized egg cell”; “In mammals, a new generation begins when an oocyte is fertilized by a sperm to form a zygote.”23 23Leung, C.Y. & Zernicka-Goetz, M., Mapping the journey from totipotency to lineage specification in the mouse embryo, Curr Opin Genet…